Autophagic Cell Death and Cancer

International Journal of Molecular Sciences

Shigeomi Shimizu¹  Tatsushi Yoshida²  Masatsune Tsujioka² 

[1] Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan;

关键词: programmed cell death;    autophagic cell death;    Atg5-independent autophagy;    Beclin1;    tumorigenesis;    c-Jun N-terminal kinase (JNK);   

DOI  :  10.3390/ijms15023145

来源: mdpi

【 摘 要 】

Programmed cell death (PCD) is a crucial process required for the normal development and physiology of metazoans. The three major mechanisms that induce PCD are called type I (apoptosis), type II (autophagic cell death), and type III (necrotic cell death). Dysfunctional PCD leads to diseases such as cancer and neurodegeneration. Although apoptosis is the most common form of PCD, recent studies have provided evidence that there are other forms of cell death. One of such cell death is autophagic cell death, which occurs via the activation of autophagy. The present review summarizes recent knowledge about autophagic cell death and discusses the relationship with tumorigenesis.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland