Synthesis, Spectroscopic and Theoretical Studies of New Quasi-Podands from Bile Acid Derivatives Linked by 1,2,3-Triazole Rings

Molecules

Tomasz Pospieszny¹  Hanna Koenig²  Iwona Kowalczyk² 

[1] Laboratory of Microbiocide Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Grunwaldzka 6, Poznań 60-780, Poland;

关键词: bile acids;    podands;    click chemistry;    1;    2;    3-triazole ring;    PM5 calculations;   

DOI  :  10.3390/molecules19022557

来源: mdpi

【 摘 要 】

A novel method for the synthesis of bile acid derivatives has been developed using “click chemistry”. Intermolecular 1,3-dipolar cycloaddition of the propargyl ester of bile acids and azide groups of 1,3,5-tris(azidomethyl)benzene gave a new quasi-podands with 1,2,3-triazole rings. The structures of the products were confirmed by spectral (¹H-NMR, ¹³C-NMR, and FT-IR) analysis, mass spectrometry and PM5 semiempirical methods. Estimation of the pharmacotherapeutic potential has been accomplished for synthesized compounds on the basis of Prediction of Activity Spectra for Substances (PASS).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.