Glycosylation of a Newly Functionalized Orthoester Derivative

Molecules

Kohei Kawa¹  Tsuyoshi Saitoh¹  Eisuke Kaji¹ 

[1] id="af1-molecules-19-02602">Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Jap

关键词: glycosylation;    orthoester;    electrogenerated acid (EGA);    Fmoc group;    selective deprotection;   

DOI  :  10.3390/molecules19022602

来源: mdpi

【 摘 要 】

Tandem glycosylation of the 6-O-Fmoc-substituted benzyl orthoester derivative 2a was carried out in moderate yields by electrogenerated acid (EGA). The Fmoc group was effectively removed under mild basic conditions, and the product was submitted to the subsequent glycosylation.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.