Chemical Composition, Biological and Cytotoxic Activities of Plant Extracts and Compounds Isolated from Ferula lutea

Molecules

Mansour Znati¹  Hichem Ben Jannet²  Sylvie Cazaux¹ 

[1] Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France;Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Médicinale et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l’Environnement, Monastir 5019, Tunisia

关键词: Ferula lutea;    (+)-Z-deltoin;    (−)-E-deltoin;    antioxidant;    antiacetylcholinesterase;    antimicrobial;    antidiabetic;    cytotoxic;    allelopathic;   

DOI  :  10.3390/molecules19032733

来源: mdpi

【 摘 要 】

The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68–52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38–14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC₅₀ = 12.8 ± 1.29 µg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 µg/mL).

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.