Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease

Nutrients

Domenico Santoro²  Giorgia Gagliostro²  Angela Alibrandi¹  Riccardo Ientile³  Guido Bellinghieri²  Vincenzo Savica²  Michele Buemi² 

[1]Department of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina 98123, Italy

[2] E-Mail:

[3]Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, Italy

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[5]Department of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina 98123, Italy

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关键词: vitamin D receptor;    gene polymorphisms;    left ventricular hypertrophy;    parathormone;    chronic kidney disease;   

DOI  :  10.3390/nu6031029

来源: mdpi

【 摘 要 】

FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.