Current Progress in Bioactive Ceramic Scaffolds for Bone Repair and Regeneration

International Journal of Molecular Sciences

Chengde Gao¹  Youwen Deng²  Pei Feng¹  Zhongzheng Mao¹  Pengjian Li¹  Bo Yang¹  Junjie Deng¹  Yiyuan Cao¹  Cijun Shuai¹ 

[1] State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China; E-Mails:;Department of Spine Surgery, the Second Xiangya Hospital of Central South University, Changsha 410011, China; E-Mail:

关键词: bioactive ceramic;    nanostructure;    pore architecture;    preparation technique;    bone repair;   

DOI  :  10.3390/ijms15034714

来源: mdpi

【 摘 要 】

Bioactive ceramics have received great attention in the past decades owing to their success in stimulating cell proliferation, differentiation and bone tissue regeneration. They can react and form chemical bonds with cells and tissues in human body. This paper provides a comprehensive review of the application of bioactive ceramics for bone repair and regeneration. The review systematically summarizes the types and characters of bioactive ceramics, the fabrication methods for nanostructure and hierarchically porous structure, typical toughness methods for ceramic scaffold and corresponding mechanisms such as fiber toughness, whisker toughness and particle toughness. Moreover, greater insights into the mechanisms of interaction between ceramics and cells are provided, as well as the development of ceramic-based composite materials. The development and challenges of bioactive ceramics are also discussed from the perspective of bone repair and regeneration.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland