International Journal of Molecular Sciences | |
Intratumoral Decorin Gene Delivery by AAV Vector Inhibits Brain Glioblastomas and Prolongs Survival of Animals by Inducing Cell Differentiation | |
Hsin-I Ma2  Dueng-Yuan Hueng2  Hao-Ai Shui3  Jun-Ming Han2  Chi-Hsien Wang2  Ying-Hsiu Lai5  Shi-Yuan Cheng4  Xiao Xiao6  Ming-Teh Chen1  | |
[1] School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan;Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan; E-Mails:;Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan; E-Mail:;Department of Neurology, Northwestern Brain Tumor Institute, The Robert H. Lurie Comprehensive Cancer Center, Center of Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; E-Mail:;Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan; E-Mail:;Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; E-Mail: | |
关键词: dsAAV; decorin; glioblastoma multiforme; proteomics; 2-D electrophoresis; | |
DOI : 10.3390/ijms15034393 | |
来源: mdpi | |
【 摘 要 】
Glioblastoma multiforme (GBM) is the most malignant cancer in the central nervous system with poor clinical prognosis. In this study, we investigated the therapeutic effect of an anti-cancer protein, decorin, by delivering it into a xenograft U87MG glioma tumor in the brain of nude mice through an adeno-associated viral (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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