Local Delivery of Antiproliferative Agents via Stents

Polymers

Hyuck Joon Kwon¹ 

[1] Department of Physical Therapy, College of Health Science, Eulji University, Gyeonggi, 461-713, Korea; E-Mail:

关键词: vascular stent;    nonvascular stent;    e-PTFE;    silicone;    polyurethane;    paclitaxel;    gemcitabine;    siRNA;   

DOI  :  10.3390/polym6030755

来源: mdpi

【 摘 要 】

A stent is a medical device for serving as an internal scaffold to maintain or increase the lumen of a body conduit. Stent placement has become a primary treatment option in coronary artery disease for more than the last two decades. The stenting is also currently used for relieving the symptoms of narrowed lumen of nonvascular organs, such as esophagus, trachea and bronchi, small and large intestines, biliary, and urinary tract. Local delivery of active pharmaceutical agents via the stents can not only enhance healing of certain diseases, but it can also help decrease the potential risk of the stenting procedure to the surrounding tissue. In this review, we focus on reviewing a variety of drug-impregnated stents and local drug delivery systems using the stents.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.