The Role of Biophysical Parameters in the Antilipopolysaccharide Activities of Antimicrobial Peptides from Marine Fish

Marine Drugs

Ramamourthy Gopal¹  Chang Ho Seo² 

[1]Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea

[2] E-Mail:

[3]Department of Bioinformatics, Kongju National University, Kongju 314-701, Korea

[4] E-Mail:

关键词: anti-lipopolysaccharide factor;    LPS-binding domain;    antimicrobial peptide;    marine fish;    innate immunity;   

DOI  :  10.3390/md12031471

来源: mdpi

【 摘 要 】

Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties of AMPs. In this review, therefore, we will focus on the physiochemical properties of AMPs; that is, the contributions made by their sequences, net charge, hydrophobicity and amphipathicity to their mechanism of action. Moreover, the interactions between LPS and fish AMPs and the structure of fish AMPs with LPS bound will also be discussed. A better understanding of the biophysical properties will be useful in the design of AMPs effective against septic shock and multidrug-resistant bacterial strains, including those that commonly produce wound infections.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.