Comparison of the Osteogenic Potential of Titanium and Modified Zirconia-Based Bioceramics

International Journal of Molecular Sciences

Young-Dan Cho¹  Ji-Cheol Shin¹  Hye-Lee Kim¹  Myagmar Gerelmaa¹  Hyung-In Yoon¹  Hyun-Mo Ryoo³  Dae-Joon Kim² 

[1] Department of Prosthodontics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea; E-Mails:;Department of Advanced Materials Engineering, Sejong University, Seoul 143-747, Korea; E-Mail:;Department of Molecular Genetics, School of Dentistry and Dental Research Institute, BK21 Program, Seoul National University, Seoul 110-749, Korea; E-Mail:

关键词: dental implant;    titanium;    zirconia;    LTD;    osteogenic potential;   

DOI  :  10.3390/ijms15034442

来源: mdpi

【 摘 要 】

Zirconia is now favored over titanium for use in dental implant materials because of its superior aesthetic qualities. However, zirconia is susceptible to degradation at lower temperatures. In order to address this issue, we have developed modified zirconia implants that contain tantalum oxide or niobium oxide. Cells attached as efficiently to the zirconia implants as to titanium-based materials, irrespective of surface roughness. Cell proliferation on the polished surface was higher than that on the rough surfaces, but the converse was true for the osteogenic response. Cells on yttrium oxide (Y₂O₃)/tantalum oxide (Ta₂O₅)- and yttrium oxide (Y₂O₃)/niobium oxide (Nb₂O₅)-containing tetragonal zirconia polycrystals (TZP) discs ((Y, Ta)-TZP and (Y, Nb)-TZP, respectively) had a similar proliferative potential as those grown on anodized titanium. The osteogenic potential of MC3T3-E1 pre-osteoblast cells on (Y, Ta)-TZP and (Y, Nb)-TZP was similar to that of cells grown on rough-surface titanium. These data demonstrate that improved zirconia implants, which are resistant to temperature-induced degradation, retain the desirable clinical properties of structural stability and support of an osteogenic response.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland