Molecules | |
Synthesis of PNA Oligoether Conjugates | |
Alice Ghidini2  Peter Steunenberg1  Merita Murtola2  | |
[1] ICL-IP Terneuzen, Frankrijkweg BJ, Terneuzen 6 4538, The Netherlands; E-Mail:;Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Hälsovägen Huddinge 7, 14183, Sweden; E-Mails: | |
关键词: peptide nucleic acid; polyethyleneglycol; aminosugar; neocuproine; | |
DOI : 10.3390/molecules19033135 | |
来源: mdpi | |
【 摘 要 】
Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues. Single and double conjugation of 2-(2-(2-aminoethoxy)ethoxy)ethanol was obtained using carbonyldimidazole. Using a post PNA-assembly coupling procedure the building block 2-(2-(2-(benzoyloxy)ethoxy)ethoxy)acetic acid multiple attachment of 2-(2-(2-hydroxyethoxy)ethoxy)acetyl groups to both N-terminal and β-amino groups of inserted diaminopropionic acids residues was achieved. Use of a new oligoether functionalized amino acid allows inclusion of oligoether conjugates during on-line machine assisted synthesis which also allowed combination of methods for attachment of different oligoethers and co-conjugation of neocuproine as well as conjugation of an aminosugar.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190027956ZK.pdf | 345KB | download |