Ochracenoids A and B, Guaiazulene-Based Analogues from Gorgonian Anthogorgia ochracea Collected from the South China Sea

Marine Drugs

Juan-Juan Zheng²  Chang-Lun Shao²  Min Chen²  Li-She Gan¹  Yu-Chun Fang²  Xu-Hui Wang² 

[1] Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; E-Mail:;Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails:

关键词: gorgonian;    Anthogorgia ochracea;    guaiazulene-based analogue;    antiproliferative effect;    zebrafish embryo;   

DOI  :  10.3390/md12031569

来源: mdpi

【 摘 要 】

Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3–6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration of 1 was determined as 3R by the comparison of TDDFT calculated electronic circular dichroism with its experimental spectrum. Compound 1 is a rare guaiazulene-based analogue possessing a unique C₁₆ skeleton. The possible generation process of 1 through an intermolecular one-carbon-transfer reaction was also discussed. Compound 2 was previously described as a presumed intermediate involved in the biogenesis of anthogorgienes A and I. Compound 3 exhibited antiproliferative effects on the embryo development of zebrafish Danio rerio.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.