Synthesis of New 2,5-Di-substituted 1,3,4-Oxadiazoles Bearing 2,6-Di-tert-butylphenol Moieties and Evaluation of Their Antioxidant Activity

Molecules

Raied M. Shakir¹  Azhar Ariffin¹ 

[1] Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail:

关键词: 2;    6-di-tert-butylphenol;    hindered phenol;    antioxidant;    1;    3;    4-oxadiazole;    FRAP;    DPPH;   

DOI  :  10.3390/molecules19033436

来源: mdpi

【 摘 要 】

Eleven new 2,6-di-tert-butyl-4-(5-aryl-1,3,4-oxadiazol-2-yl)phenols 5a–k were synthesized by reacting aryl hydrazides with 3,5-di-tert butyl 4-hydroxybenzoic acid in the presence of phosphorus oxychloride. The resulting compounds were characterized based on their IR, ¹H-NMR, ¹³C-NMR, and HRMS data. 2,2-Diphenyl-1-picrylhydrazide (DPPH) and ferric reducing antioxidant power (FRAP) assays were used to test the antioxidant properties of the compounds. Compounds 5f and 5j exhibited significant free-radical scavenging ability in both assays.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.