Nature’s Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain

Marine Drugs

Anna Lena Kunz¹  Antje Labes¹  Jutta Wiese¹  Torsten Bruhn²  Gerhard Bringmann² 

[1] Kiel Center for Marine Natural Products at the Helmholtz Center for Ocean Research (GEOMAR), Am Kiel-Kanal 44, Kiel 24106, Germany; E-Mails:;Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, Wuerzburg 97074, Germany; E-Mails:

关键词: marine natural product;    phenazine;    Baltic Sea;    Streptomyces;    Halichondria panicea;    HPLC-DAD/MS;    fermentation;    PDE 4;    antibiotic;   

DOI  :  10.3390/md12041699

来源: mdpi

【 摘 要 】

Eight streptophenazines (A–H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I–K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I–K) also showed moderate activities against PDE 4B.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.