Chemo-Electrical Signal Transduction by Using Stimuli-Responsive Polymer Gate-Modified Field Effect Transistor

Chemosensors

Akira Matsumoto²  Yusuke Tsurui¹  Hiroko Matsumoto²  Yasuhiro Maeda²  Toru Hoshi¹  Takashi Sawaguchi¹ 

[1] Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, 1-8-14 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan; E-Mails:;Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan; E-Mails:

关键词: field effect transistors;    permittivity;    Debye length;    stimuli-responsive polymers;   

DOI  :  10.3390/chemosensors2020097

来源: mdpi

【 摘 要 】

A glucose-responsive polymer brush was designed on a gold electrode and exploited as an extended gate for a field effect transistor (FET) based biosensor. A permittivity change at the gate interface due to the change in hydration upon specific binding with glucose was detectable. The rate of response was markedly enhanced compared to the previously studied cross-linked or gel-coupled electrode, owing to its kinetics involving no process of the polymer network diffusion. This finding may offer a new strategy of the FET-based biosensors effective not only for large molecules but also for electrically neutral molecules such as glucose with improved kinetics.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.