Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp

Molecules

Fei Huang³  Ruifen Zhang²  Yang Yi¹  Xiaojun Tang²  Mingwei Zhang²  Dongxiao Su³  Yuanyuan Deng² 

[1] College of Food Science & Engineering, Wuhan Polytechnic University, Wuhan 430023, China;Sericultural and Agri-food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China;Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China

关键词: litchi;    drying;    polysaccharides;    anti-tumor activity;    immunomodulatory activity;   

DOI  :  10.3390/molecules19043909

来源: mdpi

【 摘 要 】

Drying is commonly used for preservation and processing of litchi. However, its polysaccharide structure may be altered by the drying process, resulting in biological activity changes. Polysaccharides from fresh and dried litchi pulp (denoted as LPF and LPD, respectively) were isolated, investigated by GC-MS, GPC and UV/IR spectrum analysis and their antitumor and immunomodulatory activities were evaluated in vitro. LPD, the molecular weight of which was lower than that of LPF, contained more protein, uronic acid, arabinose, galactose and xylose. Compared with LPF, LPD exhibited a higher inhibitory effect on the proliferation of HepG2, Hela and A549 cells from 50–750 μg/mL. LPD was also a better stimulator of spleen lymphocyte proliferation, NK cells cytotoxicity and macrophage phagocytosis from 50–400 μg/mL. In summary, drying could change the physicochemical properties and enhance the bioactivity of polysaccharides from litchi pulp. This finding is supported by the fact that dried litchi pulps are used in Traditional Chinese Medicine.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.