International Journal of Molecular Sciences | |
Transcriptional Analysis of Apoptotic Cerebellar Granule Neurons Following Rescue by Gastric Inhibitory Polypeptide | |
Barbara Maino2  Maria Teresa Ciotti1  Pietro Calissano1  | |
[1] European Brain Research Institute, Via del Fosso di Fiorano 64, 00143 Roma, Italy; E-Mails:;Functional Genomics Center, Institute of Neurological Sciences, Italian National Research Council, Via Paolo Gaifami 18, 95126 Catania, Italy; E-Mail: | |
关键词: apoptosis; cerebellar granule neurons (CGNs); gastric inhibitory polypeptide (Gip); gene expression; rescue; survival; transcriptional program; pathway; | |
DOI : 10.3390/ijms15045596 | |
来源: mdpi | |
【 摘 要 】
Apoptosis triggered by exogenous or endogenous stimuli is a crucial phenomenon to determine the fate of neurons, both in physiological and in pathological conditions. Our previous study established that gastric inhibitory polypeptide (Gip) is a neurotrophic factor capable of preventing apoptosis of cerebellar granule neurons (CGNs), during its pre-commitment phase. In the present study, we conducted whole-genome expression profiling to obtain a comprehensive view of the transcriptional program underlying the rescue effect of Gip in CGNs. By using DNA microarray technology, we identified 65 genes, we named
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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