Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function

Molecules

Hyunil Ha¹  Ki-Shuk Shim¹  Taesoo Kim²  Hyosun An²  Chung-Jo Lee²  Kwang Jin Lee² 

[1] id="af1-molecules-19-03940">KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Kor

关键词: Acer tegmentosum;    osteoclast;    bone;    RANKL;   

DOI  :  10.3390/molecules19043940

来源: mdpi

【 摘 要 】

The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL), an essential cytokine for osteoclast differentiation. In osteoclast precursor cells, WEAT inhibited RANKL-induced activation of JNK, NF-κB, and cAMP response element-binding protein, leading to suppression of the induction of c-Fos and nuclear factor of activated T cells cytoplasmic 1, key transcription factors for osteoclast differentiation. In addition, WEAT inhibited bone resorbing activity of mature osteoclasts. Furthermore, the oral administration of WEAT reduced RANKL-induced bone resorption and trabecular bone loss in mice. Taken together, our study demonstrates that WEAT possesses a protective effect on bone destruction by inhibiting osteoclast differentiation and function.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.