International Journal of Molecular Sciences | |
Effects of Lipoic Acid on Immune Function, the Antioxidant Defense System, and Inflammation-Related Genes Expression of Broiler Chickens Fed Aflatoxin Contaminated Diets | |
Yan Li1  Qiu-Gang Ma1  Li-Hong Zhao1  Hua Wei2  Guo-Xiang Duan1  Jian-Yun Zhang1  | |
[1] State Key Laboratory of Animal Nutrition, College of Animal Science & Technology, China Agricultural University, Beijing 100193, China; E-Mails:;Translational Medicine Lab, Chinese National Human Genome Center, Beijing 100176, China; E-Mail: | |
关键词: lipoic acid; aflatoxin; alleviate; inflammation; chickens; | |
DOI : 10.3390/ijms15045649 | |
来源: mdpi | |
【 摘 要 】
This study was designed to evaluate the effect of low level of Aflatoxin B1 (AFB1) on oxidative stress, immune reaction and inflammation response and the possible ameliorating effects of dietary alpha-lipoic acid (α-LA) in broilers. Birds were randomly allocated into three groups and assigned to receive different diets: basal diet, diet containing 74 μg/kg AFB1, and 300 mg/kg α-LA supplementation in diet containing 74 μg/kg AFB1 for three weeks. The results showed that the serum levels of malondialdehyde, tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ) in the AFB1-treated group were significantly increased than the control group. In addition, the increased expressions of interleukin 6 (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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