Retinoids and Cardiac Development

Journal of Developmental Biology

Stéphane Zaffran¹  Nicolas El Robrini² 

[1] Aix Marseille Université, Génétique Médicale & Génomique Fonctionnelle (GMGF), Inserm, UMR_S910, Faculté de medicine, 27 Bd Jean Moulin, 13005 Marseille, France;

关键词: retinoic acid;    heart development;    cardiogenesis;    second heart field;    epicardium;   

DOI  :  10.3390/jdb2010050

来源: mdpi

【 摘 要 】

Retinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during cardiogenesis. Deregulated retinoid signaling thus has later consequences leading to cardiac malformations. In this review, we will summarize and discuss our current knowledge on the role of RA signaling during heart development, especially during patterning of the heart fields. We have also integrated recent experiments essential for our understanding of the role of RA signaling during epicardial development and myocardial growth.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.