Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid

Nutrients

Gianfranca Carta²  Elisabetta Murru²  Lina Cordeddu³  Berenice Ortiz⁵  Elena Giordano⁴  Martha A. Belury¹  Loredana Quadro⁶ 

[1] Department of Human Nutrition, Ohio State University, Columbus, OH 43210, USA; E-Mail:;Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, S.S. 554, km. 4500, Monserrato, Cagliari 09042, Italy; E-Mails:;Department of Bioscience and Nutrition, Karolinska Institute, Stockholm 141 83, Sweden; E-Mail:;Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, Madrid 28049, Spain; E-Mail:;Gerstner Sloan-Kettering Graduate School in Biomedical Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; E-Mail:;Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA; E-Mail:

关键词: conjugated linoleic acid (CLA);    retinol;    vitamin A;    retinol binding protein (RBP);    oleoylethanolamide (OEA);    palmitoylethanolamide (PEA);    peroxisome proliferator-activated receptor-alpha (PPARα);   

DOI  :  10.3390/nu6031262

来源: mdpi

【 摘 要 】

Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.