Molecules | |
Synthesis and Biological Activity of Some Bile Acid-Based Camptothecin Analogues | |
Xingnuo Li1  Tengfei Zhao2  Dongping Cheng1  Chu Chu1  Shengqiang Tong1  Jizong Yan1  | |
[1] College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; E-Mails:;Key Laboratory of Forest Plant Ecology (Northeast Forestry University), Ministry of Education, 332# No. 26 Hexing Road, Harbin 150040, China; E-Mail: | |
关键词: camptothecin; bile acids; anti-tumour activity; hepatoma cells; | |
DOI : 10.3390/molecules19033761 | |
来源: mdpi | |
【 摘 要 】
In an effort to decrease the toxicity of camptothecin (CPT) and improve selectivity for hepatoma and colon cancer cells, bile acid groups were introduced into the CPT 20 or 10 positions, resulting in the preparation of sixteen novel CPT-bile acid analogues. The compounds in which a bile acid group was introduced at the 20-hydroxyl group of CPT showed better cytotoxic selectivity for human hepatoma and colon cancer cells than for human breast cancer cells. Fluorescence microscopy analysis demonstrated that one compound (
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
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