Further Mulinane and Azorellane Diterpenoids Isolated from Mulinum crassifolium and Azorella compacta

Molecules

Jorge Bórquez³  Alejandro Ardiles³  Luis Alberto Loyola³  Luis Manuel Pe༚-Rodriguez¹  Gloria Mar໚ Molina-Salinas²  Javier Vallejos⁵  Isidro G. Collado⁴ 

[1] Grupo de Química Orgánica, Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43 No 130, Colonia Chuburná, Mérida, Yucatán 97200, Mexico; E-Mail:;División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social, San Luis Potosí y Dos de Abril, Colonia Independencia, Monterrey, Nuevo León 64720, Mexico; E-Mail:;Laboratorio de Productos Naturales, Departamento de Química, Universidad de Antofagasta, Av. Coloso S-N, Antofagasta 1240000, Chile; E-Mails:;Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apartado Postal 40, Puerto Real 11510, Spain; E-Mail:;Departamento de Química, Universidad Católica del Norte, Av. Angamos 610, Antofagasta 1240000, Chile; E-Mail:

关键词: mulinanes;    azorellanes;    new diterpenoids;    Chilean native plants;    semisynthesis;   

DOI  :  10.3390/molecules19043898

来源: mdpi

【 摘 要 】

The new mulinane diterpenoids 1 and 2 were isolated from the EtOAc extract of Mulinum crassifolium, while the rearranged mulinane 5, which was isolated for the first time from a natural source, was isolated from Azorella compacta. Compounds 1–2 were prepared by semi-synthesis thorough acetylation of the diterpene 17-acetoxymulinic acid (3). A mechanism of reaction was proposed, while the structures of the new compounds were elucidated on the basis of comprehensive spectroscopic analysis and computational methods.

【 授权许可】

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.