Molecules | |
Chemo-Enzymatic Synthesis of Silybin and 2,3-Dehydrosilybin Dimers | |
Eva Vavříková1  Jan Vacek2  Kateřina Valentová1  Petr Marhol1  Jitka Ulrichová2  Marek Kuzma1  | |
[1]Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ-142 20 Prague 4, Czech Republic | |
[2] E-Mails: | |
[3]Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 3, CZ-775 15 Olomouc, Czech Republic | |
[4] E-Mails: | |
关键词: flavonolignan; silybin; silibinin; dimerization; electrochemistry; antioxidant; microsomal lipid peroxidation; HUVEC; cytotoxicity; | |
DOI : 10.3390/molecules19044115 | |
来源: mdpi | |
【 摘 要 】
Divalent or multivalent molecules often show enhanced biological activity relative to the simple monomeric units. Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190027395ZK.pdf | 1000KB | download |