Placotylene A, an Inhibitor of the Receptor Activator of Nuclear Factor-κB Ligand-Induced Osteoclast Differentiation, from a Korean Sponge Placospongia sp.

Marine Drugs

Hiyoung Kim²  Kwang-Jin Kim³  Jeong-Tae Yeon⁴  Seong Hwan Kim⁵  Dong Hwan Won²  Hyukjae Choi¹  Sang-Jip Nam⁶  Young-Jin Son³ 

[1] College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea; E-Mail:;Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea; E-Mails:;Department of Pharmacy, Sunchon National University, 315 Maegok-dong, Suncheon, Jeollanam-do 540-742, Korea; E-Mail:;Research Institute of Basic Science, Sunchon National University, Suncheon 540-742, Korea; E-Mail:;Laboratory of Translational Therapeutics, Pharmacology Research Center, Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Daejeon 305-600, Korea; E-Mail:;Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea; E-Mail:

关键词: Placospongia;    sponge;    RANKL;    osteoclasts;   

DOI  :  10.3390/md12042054

来源: mdpi

【 摘 要 】

A new inhibitor, placotylene A (1), of the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation, and a regioisomer of placotylene A, placotylene B (2), were isolated from a Korean marine sponge Placospongia sp. The chemical structures of placotylenes A and B were elucidated on the basis of 1D and 2D NMR, along with MS spectral analysis and revealed as an iodinated polyacetylene class of natural products. Placotylene A (1) displayed inhibitory activity against RANKL-induced osteoclast differentiation at 10 μM while placotylene B (2) did not show any significant activity up to 100 μM, respectively.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.