Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007

Marine Drugs

Yi Wang²  Liping Wang²  Yibin Zhuang²  Fandong Kong²  Cuixian Zhang¹ 

[1]School of Chinese Material Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

[2] E-Mail:

[3]Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

[4] E-Mails:

关键词: Penicillium sp.;    Streptomyces fradiae;    co-cultivation;    secondary metabolites;    cytotoxicity;   

DOI  :  10.3390/md12042079

来源: mdpi

【 摘 要 】

Penicillium sp. WC-29-5 was co-cultured with Streptomyces fradiae 007 to produce five natural products (1–3, 4a and 4b) that were isolated and characterized by spectroscopic analysis. Interestingly, these compounds were found to be different from those produced in discrete fungal and bacterial controls. Among these compounds, the absolute configurations of compounds 4a and 4b were determined for the first time by X-ray single crystal diffraction experiments and electronic circular dichroism (ECD) calculations. An evaluation of the cytotoxic activities of these compounds revealed that 4b was moderately cytotoxic towards HL-60 and H1975 tumor cells with IC₅₀ values of 3.73 and 5.73 µM, respectively, whereas compound 4a was only moderately cytotoxic towards H1975 cells with an IC₅₀ value of 3.97 µM.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.