Cancers | |
Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance | |
Gabriele Multhoff2  Jürgen Radons1  | |
[1] multimmune GmbH, Munich, Ismaningerstr. 22, 81675 Munich, Germany; E-Mail:;Department of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany; E-Mail: | |
关键词: tumor angiogenesis; tumor microcirculation; tumor hypoxia; hypoxia-inducible factor (HIF); radioresistance; hypoxia modifiers; | |
DOI : 10.3390/cancers6020813 | |
来源: mdpi | |
【 摘 要 】
Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190027244ZK.pdf | 502KB | download |