Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

Cancers

Gabriele Multhoff²  Jürgen Radons¹ 

[1] multimmune GmbH, Munich, Ismaningerstr. 22, 81675 Munich, Germany; E-Mail:;Department of Radiotherapy and Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany; E-Mail:

关键词: tumor angiogenesis;    tumor microcirculation;    tumor hypoxia;    hypoxia-inducible factor (HIF);    radioresistance;    hypoxia modifiers;   

DOI  :  10.3390/cancers6020813

来源: mdpi

【 摘 要 】

Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.