International Journal of Molecular Sciences | |
Single and Binge Methamphetamine Administrations Have Different Effects on the Levels of Dopamine D2 Autoreceptor and Dopamine Transporter in Rat Striatum | |
Heli Chauhan1  Bryan A. Killinger1  Cheryl V. Miller1  | |
[1] Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences at Wayne State University, 259 Mack Ave, Detroit, MI 48201, USA; | |
关键词:
dopamine D2 receptor;
dopamine transporter;
methamphetamine;
striatum;
|
|
DOI : 10.3390/ijms15045884 | |
来源: mdpi | |
【 摘 要 】
Methamphetamine (METH) is a central nervous system psychostimulant with a high potential for abuse. At high doses, METH causes a selective degeneration of dopaminergic terminals in the striatum. Dopamine D2 receptor antagonists and dopamine transporter (DAT) inhibitors protect against neurotoxicity of the drug by decreasing intracellular dopamine content and, consequently, dopamine autoxidation and production of reactive oxygen species.
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190027223ZK.pdf | 658KB | download |