International Journal of Molecular Sciences | |
Importance of |
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Yang Bai1  Wan Huang1  Li-Tian Ma1  Jian-Li Jiang1  | |
关键词:
CD147;
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DOI : 10.3390/ijms15046356 | |
来源: mdpi | |
【 摘 要 】
Glycosylation of glycoproteins is one of many molecular changes that accompany malignant transformation. Post-translational modifications of proteins are closely associated with the adhesion, invasion, and metastasis of tumor cells. CD147, a tumor-associated antigen that is highly expressed on the cell surface of various tumors, is a potential target for cancer diagnosis and therapy. A significant biochemical property of CD147 is its high level of glycosylation. Studies on the structure and function of CD147 glycosylation provide valuable clues to the development of targeted therapies for cancer. Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
【 预 览 】
Files | Size | Format | View |
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RO202003190027080ZK.pdf | 656KB | download |