A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal Brain

Brain Sciences

Sunny Chiao¹ 

[1] Department of Anesthesiology, University of Virginia, Charlottesville, VA 22908, USA; E-Mail

关键词: anesthesia;    anesthetics;    neuroprotection;    neurotoxicity;    pediatrics;    volatile anesthetics;    preconditioning;    postconditioning;    ischemic conditioning;   

DOI  :  10.3390/brainsci4020273

来源: mdpi

【 摘 要 】

The use of volatile anesthetics, a group of general anesthetics, is an exceedingly common practice. These anesthetics may have neuroprotective effects. Over the last decade, anesthetic induced neurotoxicity in pediatric populations has gained a certain notoriety based on pre-clinical cell and animal studies demonstrating that general anesthetics may induce neurotoxicity, including neuroapoptosis, neurodegeneration, and long-term neurocognitive and behavioral deficits. With hundreds of millions of people having surgery under general anesthesia worldwide, and roughly six million children annually in the U.S. alone, the importance of clearly defining toxic or protective effects of general anesthetics cannot be overstated. Yet, with our expanding body of knowledge, we have come to learn that perhaps not all volatile anesthetics have the same pharmacological profiles; certain ones may have a more favorable neurotoxic profile and may actually exhibit neuroprotection in specific populations and situations. Thus far, very few clinical studies exist, and have not yet been convincing enough to alter our practice. This review will provide an update on current data regarding volatile anesthetic induced neurotoxicity and neuroprotection in neonatal and infant populations. In addition, this paper will discuss ongoing studies and the trajectory of further research over the coming years.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.