A Benzoic Acid Derivative and Flavokawains from Piper species as Schistosomiasis Vector Controls

Molecules

Ludmila N. Rapado⁵  Giovana C. Freitas⁴  Adriano Polpo²  Maritza Rojas-Cardozo³  Javier V. Rincón³  Marcus T. Scotti¹  Massuo J. Kato⁴  Eliana Nakano⁵ 

[1] Centro de Ciências Aplicadas e Educação, Universidade Federal da Paraíba, Campus IV, Rua da Mangueira, s/n, Rio Tinto, PB, CEP 5829-7000, Brazil; E-Mail:;Departamento de Estatística, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Via Washington Luís, km 235, Sao Carlos, SP, Caixa-postal 676, CEP 13565-905, Brazil; E-Mail:;Department of Pharmacy, Faculty of Sciences, Universidad Nacional de Colombia, Kr 30 45-03, Bogotá, Colombia; E-Mails:;Research Support Center in Diversity of Natural Products, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, sala 1124, São Paulo, SP, CEP 05508-000, Brazil; E-Mails:;Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP, CEP 05503-900, Brazil; E-Mail:

关键词: schistosomiasis;    molluscicide;    benzoic acid;    flavokawain;    Piper;   

DOI  :  10.3390/molecules19045205

来源: mdpi

【 摘 要 】

The search of alternative compounds to control tropical diseases such as schistosomiasis has pointed to secondary metabolites derived from natural sources. Piper species are candidates in strategies to control the transmission of schistosomiasis due to their production of molluscicidal compounds. A new benzoic acid derivative and three flavokawains from Piper diospyrifolium, P. cumanense and P. gaudichaudianum displayed significant activities against Biomphalaria glabrata snails. Additionally, “in silico” studies were performed using docking assays and Molecular Interaction Fields to evaluate the physical-chemical differences among the compounds in order to characterize the observed activities of the test compounds against Biomphalaria glabrata snails.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.