Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

Nutrients

Fiona E. Harrison²  Gene L. Bowman¹ 

[1] Brain Institute, Department of Neurology, NIA–Aging and Alzheimer’s Disease Center Oregon Health and Science University, Portland, OR 97239, USA; E-Mail:;Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA; E-Mail:

关键词: ascorbic acid;    vitamin C;    brain;    cognitive function;    alzheimer’s disease;    dementia;    aging;    elderly;    endothelial function;    blood-brain barrier;    SVCT (sodium-dependent vitamin C transporter);   

DOI  :  10.3390/nu6041752

来源: mdpi

【 摘 要 】

This review is focused upon the role of ascorbic acid (AA, vitamin C) in the promotion of healthy brain aging. Particular attention is attributed to the biochemistry and neuronal metabolism interface, transport across tissues, animal models that are useful for this area of research, and the human studies that implicate AA in the continuum between normal cognitive aging and age-related cognitive decline up to Alzheimer’s disease. Vascular risk factors and comorbidity relationships with cognitive decline and AA are discussed to facilitate strategies for advancing AA research in the area of brain health and neurodegeneration.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.