Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

Molecules

Aymn E. Rashad¹  Ahmed H. Shamroukh¹  Randa E. Abdel-Megeid¹ 

[1] Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt; E-Mails:

关键词: pyrazoles;    pyrazolopyrimidines;    pyrazolotriazolopyrimidines;    isomerization;   

DOI  :  10.3390/molecules19055459

来源: mdpi

【 摘 要 】

4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.