High Plasma Homocysteine Increases Risk of Metabolic Syndrome in 6 to 8 Year Old Children in Rural Nepal

Nutrients

Mohsin Yakub¹  Kerry J. Schulze¹  Subarna K. Khatry³  Christine P. Stewart²  Parul Christian¹ 

[1] Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; E-Mails:;Program in International and Community Nutrition, University of California, Davis, CA 95616, USA; E-Mail:;Nepal Nutrition Intervention Project-Sarlahi, Tripureswor, Kathmandu 45104, Nepal; E-Mail:

关键词: metabolic syndrome;    homocysteine;    Nepal;   

DOI  :  10.3390/nu6041649

来源: mdpi

【 摘 要 】

Little attention has been given to the association of plasma homocysteine (Hcy) and metabolic syndrome (MetS) in children. We have evaluated the risk of MetS with plasma Hcy in a cohort of 6 to 8 year old rural Nepalese children, born to mothers who had participated in an antenatal micronutrient supplementation trial. We assessed Hcy in plasma from a random selection of n = 1000 children and determined the relationship of elevated Hcy (>12.0 μmol/L) to MetS (defined as the presence of any three of the following: abdominal adiposity (waist circumference ≥ 85th percentile of the study population), high plasma glucose (≥85th percentile), high systolic or diastolic blood pressure (≥90th percentile of reference population), triglyceride ≥ 1.7 mmol/L and high density lipoprotein < 0.9 mmol/L.) and its components. There was an increased risk of low high-density lipoproteins (HDL), [odds ratios (OR) = 1.77, 95% confidence intervals (CI) = 1.08–2.88; p = 0.020], high blood pressure [OR = 1.60, 95% CI = 1.10–2.46; p = 0.015] and high body mass index (BMI) [OR = 1.98, 95% CI = 1.33–2.96; p = 0.001] with elevated Hcy. We observed an increased risk of MetS (OR = 1.75, 95% CI = 1.06–2.90; p = 0.029) with elevated Hcy in age and gender-adjusted logistic regression models. High plasma Hcy is associated with increased risk of MetS and may have implications for chronic disease later in life.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.