miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives

Molecules

Andreas Gisel³  Mirna Valvano³  Imane Ghafir El Idrissi²  Patrizia Nardulli¹  Amalia Azzariti¹  Antonio Carrieri⁴  Marialessandra Contino⁴ 

[1] Clinical and Preclinical Pharmacology Laboratory, National Cancer Research Centre, Istituto Tumori Giovanni Paolo II, Viale O. Flacco, 65, Bari 70124, Italy; E-Mails:;Biofordrug srl, Università degli Studi di Bari, via Orabona 4, Bari 70125, Italy; E-Mail:;Institute for Biomedical Technologies, CNR Bioinformatics and Genomics Research Group, Via Amendola 122/D, Bari 70126, Italy; E-Mails:;Università degli Studi di Bari “Aldo Moro”, Via Orabona 4, Bari 70125, Italy; E-Mails:

关键词: microRNAs;    MDR;    early diagnosis;    MDCK-MDR1;    P-glycoprotein;   

DOI  :  10.3390/molecules19055611

来源: mdpi

【 摘 要 】

The goal of the present paper is to establish and validate the link between cancer diagnosis and therapy by microRNAs detection. The induction in vitro of some specific microRNAs after treatment with MDR ligands has been outlined. Starting from the results obtained by in vitro induction of MDCK and MDCK-MDR1 cells treated by a MDR1 ligand, a new scenario in the early diagnosis and chemotherapy could be disclosed. To corroborate this perspective a short overview on pancreatic cancer diagnosis and chemotherapeutic treatment has been reported.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.