SHSST Cyclodextrin Complex Prevents the Fibrosis Effect on CCl4-Induced Cirrhotic Cardiomyopathy in Rats through TGF-β Pathway Inhibition Effects

International Journal of Molecular Sciences

Cheng-Hsun Yang³  Wei-Jen Ting⁵  Cecilia Hsuan Day⁴  Da-Tong Ju¹  Yu-Lan Yeh⁷  Li-Chin Chung²  Fu-Jenn Tsai⁶  Chang-Hai Tsai⁸  Yuhsin Tsai³ 

[1] Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Chenggong Road, Neihu District, Taipei 114, Taiwan; E-Mail:;Department of Hospital and Health Care Administration, China Nan University of Pharmacy & Science, 60, Section 1, Erren Road, Rende District, Tainan 71710, Taiwan; E-Mail:;Graduate Institute of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan; E-Mail:;Department of Nursing, Mei Ho University, 23 Pingguang Road, Pingtung 91202, Taiwan; E-Mail:;Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan; E-Mail:;School of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan; E-Mail:;Department of Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua 50006, Taiwan; E-Mail:;Department of Healthcare Administration, Asia University, 500 Lioufeng Road, Taichung 41354, Taiwan; E-Mail:

关键词: San Huang Shel Shin Tang;    silymarin;    baicalein;    cirrhotic cardiomyopathy;   

DOI  :  10.3390/ijms15058037

来源: mdpi

【 摘 要 】

Patients with liver cirrhosis also have subtle cardiac structure or function abnormalities. This cardiac dysfunction commonly occurs in 56% of waiting orthotopic liver transplantation (OLT) patients and is defined as cirrhotic cardiomyopathy (CCM). Up to now, there is no standard treatment because CCM does not have a solidly established diagnosis and is based on high clinical suspicion. The liver function of CCM is particularly limited, making patients vulnerable to more drug treatments. Here, we use silymarin (100 mg/kg/day), baicalein (30 mg/kg/day), San Huang Shel Shin Tang (SHSST, 30 mg/kg/day) and β-cyclodextrin modified SHSST (SHSSTc, 30 and 300 mg/kg/day) treatments for a CCl₄-induced CCM rat model. The results show that silymarin, baicalein and SHSST treatments can only slightly reduce the collagen accumulation in CCM rat hearts. However, SHSSTc treatment protects the heart in CCM and significantly inhibits collagen acumination and the fibrosis regulating transforming growth factor-β (TGF-β) pathway expression. SHSSTc treatments further reduced the heart weight and the ratio between left ventricular weight (LVW) and tibia length (TL). This experimental data show that water solubility improved β-cyclodextrin modified Chinese herbal medicine formula (SHSSTc) can provide an excellent heart protection effect through TGF-β pathway inhibition.

【 授权许可】

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