Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases

Marine Drugs

Clara Grosso²  Patrໜia Valentão²  Federico Ferreres¹ 

[1] Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, Campus University Espinardo, Murcia 30100, Spain; E-Mail:;REQUIMTE/Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, no. 228, 4050-313 Porto, Portugal; E-Mails:

关键词: aragonite;    conotoxins;    neurodegeneration;    neuroinflammation;    Aβ peptide;    tau hyperphosphorylation;    protein kinases;    receptors;    voltage-dependent ion channels;    cyclooxygenases;   

DOI  :  10.3390/md12052539

来源: mdpi

【 摘 要 】

Marine invertebrates produce a plethora of bioactive compounds, which serve as inspiration for marine biotechnology, particularly in drug discovery programs and biomaterials development. This review aims to summarize the potential of drugs derived from marine invertebrates in the field of neuroscience. Therefore, some examples of neuroprotective drugs and neurotoxins will be discussed. Their role in neuroscience research and development of new therapies targeting the central nervous system will be addressed, with particular focus on neuroinflammation and neurodegeneration. In addition, the neuronal growth promoted by marine drugs, as well as the recent advances in neural tissue engineering, will be highlighted.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.