Optimization of Cell Adhesion on Mg Based Implant Materials by Pre-Incubation under Cell Culture Conditions

International Journal of Molecular Sciences

Regine Willumeit¹  Anneke Möhring² 

[1] Helmholtz-Zentrum Geesthacht, Institute of Materials Research, Max-Planck-Str. 1, Geesthacht 21502, Germany;

关键词: magnesium implants;    natural corrosion protection;    pre-incubation;    biocompatibility;   

DOI  :  10.3390/ijms15057639

来源: mdpi

【 摘 要 】

Magnesium based implants could revolutionize applications where orthopedic implants such as nails, screws or bone plates are used because they are load bearing and degrade over time. This prevents a second surgery to remove conventional implants. To improve the biocompatibility we studied here if and for how long a pre-incubation of the material under cell culture conditions is favorable for cell attachment and proliferation. For two materials, Mg and Mg10Gd1Nd, we could show that 6 h pre-incubation are already enough to form a natural protective layer suitable for cell culture.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland