Two Polycyclic Geranylhydroquinone-Derived Metabolites from Roots of Arnebia hispidissima (Lehm.) DC.

Molecules

Atallah F. Ahmed¹  Hassan-Elrady A. Saad² 

[1] Department of Pharmacognosy, College of Pharmacy, King Saud University (KSU), Riyadh 11451, Kingdom of Saudi Arabia;Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University (MU), Mansoura 35516, Egypt

关键词: Arnebia hispidissima;    arnebacene;    arnebidin;    arnebin-7;    phenolic compounds;    geranylhydroquinone;   

DOI  :  10.3390/molecules19055940

来源: mdpi

【 摘 要 】

A phytochemical investigation of the least polar organic extracts of Arnebia hispidissima (Lehm.) DC. roots has led to the isolation of two unique polycyclic geranylhydroquinone-derived metabolites, arnebacene (1) and arnebidin (2), along with some known phenolic metabolites viz., arnebin-7 (3) and vanillic acid (4). The chemical identification of the new isolated compounds, including their relative stereochemistry, was achieved via spectroscopic analyses, including 2D NMR, and spectral comparison with related compounds. A biosynthetic pathway is proposed for the new compounds on the basis of their structure-relationship with previously isolated metabolites.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.