Exploiting Natural Products to Build Metalla-Assemblies: The Anticancer Activity of Embelin-Derived Rh(III) and Ir(III) Metalla-Rectangles

Molecules

Gajendra Gupta¹  Jerald Mahesh Kumar²  Amine Garci¹  Narayana Nagesh² 

[1] Institute of Chemistry, University of Neuchatel, Avenue de Bellevaux 51, CH-2000 Neuchatel, Switzerland; E-Mails:;CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad-500 007, India; E-Mail:

关键词: bioinorganic chemistry;    metalla-assemblies;    coordination-driven self-assembly;    anticancer activity;    half-sandwich complexes;   

DOI  :  10.3390/molecules19056031

来源: mdpi

【 摘 要 】

Six new pentamethylcyclopentadienyl Rh(III) and Ir(III) metalla-rectangles ([3](CF₃SO₃)₄–[8](CF₃SO₃)₄) have been prepared by a self-assembly strategy using the embelin-derived metalla-clips (η⁵-C₅Me₅)₂M₂(μ₄-C₆HRO₄-κO)Cl₂ (M = Rh, 1; M = Ir, 2; R = (CH₂)₁₀CH₃) and the linear ditopic ligands, pyrazine, 4,4'-bipyridine and 1,2-bis(4-pyridyl)ethylene. These new metalla-rectangles have been obtained in high yield and isolated as their triflate salts. The complexes have been fully characterized by standard spectroscopic techniques and the antiproliferative activity of these tetranuclear complexes was evaluated in vitro on cancerous (DU-145, A-549, HeLa) and noncancerous (HEK-293) cell lines. The biological study has showed a better activity for the rhodium derivatives over the iridium analogs and for all complexes a very good selectivity for cancerous over noncancerous cells. The presence of lipophilic side chains coupled with the positive charge of the tetranuclear complexes suggested a cytotoxic activity involving the mitochondrial machinery, as demonstrated by multiple biological experiments.

【 授权许可】

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