International Journal of Molecular Sciences | |
The G Protein-Coupled Receptor Heterodimer Network (GPCR-HetNet) and Its Hub Components | |
Dasiel O. Borroto-Escuela2  Ismel Brito2  Wilber Romero-Fernandez2  Michael Di Palma2  Julia Oflijan4  Kamila Skieterska5  Jolien Duchou5  Kathleen Van Craenenbroeck5  Diana Suárez-Boomgaard3  Alicia Rivera3  Diego Guidolin1  Luigi F. Agnati2  | |
[1]Department of Molecular Medicine, University of Padova, Padova 35121, Italy | |
[2] E-Mail: | |
[3]Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177 Stockholm, Sweden | |
[4] E-Mails: | |
[5]Department of Cell Biology, School of Science, University of Málaga, 29071 Málaga, Spain | |
[6] E-Mails: | |
[7]Department of Physiology, Faculty of Medicine, University of Tartu, Tartu 50411, Estonia | |
[8] E-Mail: | |
[9]Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Ghent University, 9000 Ghent, Belgium | |
[10] E-Mails: | |
关键词: G protein-coupled receptors; network; heterodimerization; heteromers; dimerization; oligomerization; hubs; receptor-receptor interactions; clusters; architecture; | |
DOI : 10.3390/ijms15058570 | |
来源: mdpi | |
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【 摘 要 】
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner. However, despite the current development of experimental techniques for large-scale detection of GPCR heteromers, in order to understand their connectivity it is necessary to develop novel tools to study the global heteroreceptor networks. To provide insight into the overall topology of the GPCR heteromers and identify key players, a collective interaction network was constructed. Experimental interaction data for each of the individual human GPCR protomers was obtained manually from the STRING and SCOPUS databases. The interaction data were used to build and analyze the network using Cytoscape software. The network was treated as undirected throughout the study. It is comprised of 156 nodes, 260 edges and has a scale-free topology. Connectivity analysis reveals a significant dominance of intrafamily
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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