CERN-MEDICIS (Medical Isotopes Collected from ISOLDE): A New Facility

Applied Sciences

Ricardo Manuel dos Santos Augusto¹  Leo Buehler²  Zoe Lawson¹  Stefano Marzari¹  Monika Stachura¹  Thierry Stora¹ 

[1] CERN, 23 Geneva, 1211-Geneva, Switzerland; E-Mails:;Hôpitaux Universitaires de Genève (HUG), Rue Gabrielle-Perret-Gentil 4, 1205-Geneva, Switzerland; E-Mail:

关键词: CERN-MEDICIS;    ISOLDE;    CERN;    radioisotope;    radiolanthanides;    bioconjugates;    targeted radiotherapy;    targeted alpha therapy (TAT);    cancer;    PET imaging;    theranostics;   

DOI  :  10.3390/app4020265

来源: mdpi

【 摘 要 】

About 50% of the 1.4 GeV CERN (European Organization for Nuclear Research, www.cern.ch) protons are sent onto targets to produce radioactive beams by online mass separation at the Isotope Separator Online Device (ISOLDE) facility, for a wide range of studies in fundamental and applied physics. CERN-MEDICIS is a spin-off dedicated to R&D in life sciences and medical applications. It is located in an extension of the Class A building presently under construction. It will comprise laboratories to receive the irradiated targets from a new station located at the dump position behind the ISOLDE production targets. An increasing range of innovative isotopes will thus progressively become accessible from the start-up of the facility in 2015 onward; for fundamental studies in cancer research, for new imaging and therapy protocols in cell and animal models and for pre-clinical trials, possibly extended to specific early phase clinical studies up to Phase I trials. Five hundred megabecquerel isotope batches purified by electromagnetic mass separation combined with chemical methods will be collected on a weekly basis. A possible future upgrade with gigabecquerel pharmaceutical-grade i.e., current good manufacturing practices (cGMP) batch production capabilities is finally presented.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.