Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

Marine Drugs

Christina Viegelmann¹  Jennifer Parker¹  Thengtheng Ooi¹  Carol Clements¹  Gráinne Abbott¹  Louise Young¹  Jonathan Kennedy²  Alan D. W. Dobson² 

[1] Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow, Scotland G4 0RE, UK; E-Mails:;Marine Biotechnology Centre, Environmental Research Institute, University College Cork, Lee Road, Cork, Ireland; E-Mails:

关键词: Haliclona simulans;    marine sponges;    steroids;    antitrypanosomal;    anti-mycobacterial;   

DOI  :  10.3390/md12052937

来源: mdpi

【 摘 要 】

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and 20-methyl-pregn-6-en-3β-ol,5α,8α-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact- and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.