The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment

Molecules

Marco D𠆚nzeo¹  Luca Faloppi¹  Mario Scartozzi¹  Riccardo Giampieri¹  Maristella Bianconi¹  Michela Del Prete¹  Nicola Silvestris² 

[1]Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. “Ospedali Riuniti” Via Conca 71, 60126 Ancona, Italy

[2] E-Mails:

[3]Istituto Oncologico “Giovanni Paolo II”, I.R.C.S.S. Ospedale Oncologico di Bari, Viale Orazio Flacco 65, 70124 Bari, Italy

[4] E-Mail:

关键词: HCC;    hepatocellular carcinoma;    miRNAs;   

DOI  :  10.3390/molecules19056393

来源: mdpi

【 摘 要 】

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.