CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts

Molecules

Dong-Hee Kim¹  Han-Hyuk Kim³  Hyeon-Jeong Kim⁴  Hyun-Gug Jung²  Jae-Myo Yu⁴  Eun-Su Lee⁴  Yong-Hun Cho⁴  Dong-In Kim⁴ 

[1] Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan 712-260, Korea;Radiation Division for Biotechnology, Advanced Radiation Technology Institute, Jeongeup Campus of Atomic Energy Research Institute (KAERI), Jeonbuk 580-185, Korea;Advanced Medical Fusion Textile Center, Gyeongbuk Technopark Foundation, Gyeongsan 712-210, Korea;Department of Cosmeceutical Science, Daegu Haany University, Gyeongsan 712-715, Korea

关键词: Copris tripartitus;    CopA3;    ultraviolet;    matrix metalloproteinase-1;    CCD-986sk cells;   

DOI  :  10.3390/molecules19056407

来源: mdpi

【 摘 要 】

Ultraviolet (UV) exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1) activity. A 9-mer peptide, CopA3 (CopA3) was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 μM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.