Molecules | |
Synthesis and Antibacterial Activity of Amino Acid and Dipeptide Prodrugs of IMB-070593, a Fluoroquinolone Candidate | |
Tingting Zhang3  Jinwei Wu1  Shihong Chen1  Kaixiang Liu2  Yabin Lin4  Huiyuan Guo3  | |
[1] Zhejiang Starry Pharmaceutical Co. Ltd., Xianju 317300, China;China Resources Double-Crane Pharmaceutical Co. Ltd., Beijing 100102, China;Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Harbin Stomatological Hospital, Harbin 150010, China | |
关键词: IMB-070593; prodrugs; synthesis; water solubility; antibacterial activity; | |
DOI : 10.3390/molecules19056822 | |
来源: mdpi | |
【 摘 要 】
A series of amino acid and dipeptide prodrugs of IMB-070593, a fluoroquinolone candidate discovered in our lab, were synthesized and evaluated for their water solubility and then antibacterial activity. Our results reveal that four amino acid prodrugs
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190025769ZK.pdf | 286KB | download |