Physiological Function and Characterization of TRPCs in Neurons

Cells

Yuyang Sun²  Pramod Sukumaran²  Bidhan C. Bandyopadhyay¹ 

[1] Calcium Signaling Laboratory, Research Service, Veterans Affairs Medical Center, Washington, DC 20422, USA;Department of Basic Science, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58201, USA

关键词: Ca²⁺;    TRPC channels;    neuronal function;    neurodegenerative diseases;   

DOI  :  10.3390/cells3020455

来源: mdpi

【 摘 要 】

Ca²⁺ entry is essential for regulating vital physiological functions in all neuronal cells. Although neurons are engaged in multiple modes of Ca²⁺ entry that regulates variety of neuronal functions, we will only discuss a subset of specialized Ca²⁺-permeable non-selective Transient Receptor Potential Canonical (TRPC) channels and summarize their physiological and pathological role in these excitable cells. Depletion of endoplasmic reticulum (ER) Ca²⁺ stores, due to G-protein coupled receptor activation, has been shown to activate TRPC channels in both excitable and non-excitable cells. While all seven members of TRPC channels are predominately expressed in neuronal cells, the ion channel properties, mode of activation, and their physiological responses are quite distinct. Moreover, many of these TRPC channels have also been suggested to be associated with neuronal development, proliferation and differentiation. In addition, TRPCs also regulate neurosecretion, long-term potentiation and synaptic plasticity. Similarly, perturbations in Ca²⁺ entry via the TRPC channels have been also suggested in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of TRPCs in neuronal function and in neurodegenerative conditions would presumably unveil avenues for plausible therapeutic interventions for these devastating neuronal diseases.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.