International Journal of Molecular Sciences | |
Functional Polymorphisms of the |
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Danqiu Zhou3  Yunqing Liu4  Xinju Zhang1  Xiaoye Gu1  Hua Wang1  Xinhua Luo2  Jin Zhang2  Hejian Zou5  | |
[1] Central Laboratory, Huashan Hospital, Fudan University, 12 Central Urumqi Road, Shanghai 200040, China; E-Mails:;Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang, China; E-Mails:;Department of Laboratory Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China; E-Mail:;Department of Laboratory Medicine, Renhe Hospital, Baoshan District, Shanghai 200443, China; E-Mail:;Department of Rheumatology, Huashan Hospital, Fudan University, Shanghai 200040, China; E-Mail: | |
关键词: gout; uric acid; polymorphism; ABCG2; | |
DOI : 10.3390/ijms15059149 | |
来源: mdpi | |
【 摘 要 】
Gout is a common type of arthritis that is characterized by hyperuricemia, tophi and joint inflammation. Genetic variations in the Peripheral blood DNA was isolated from 352 male patients with gout and 350 gout-free normal male controls. High-resolution melting analysis and Sanger sequencing were performed to identify the genetic polymorphisms V12M, Q141K and Q126X in the For Q141K, the A allele frequency was 49.6% in the gout patients and 30.9% in the controls (OR 2.20, 95% confidence interval (CI): 1.77–2.74, The
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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