New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp. SCSIO 05240

Marine Drugs

Mangaladoss Fredimoses¹  Xuefeng Zhou¹  Xiuping Lin²  Xinpeng Tian²  Wen Ai²  Junfeng Wang²  Shengrong Liao²  Juan Liu²  Bin Yang²  Xianwen Yang² 

[1] Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China;

关键词: prenylxanthone;    Emericella;    deep-sea;    fungus;   

DOI  :  10.3390/md12063190

来源: mdpi

【 摘 要 】

Four new prenylxanthones, emerixanthones A–D (1–4), together with six known analogues (5–10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (¹H, ¹³C NMR, HSQC, HMBC, and ¹H-¹H COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1 and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.