NOD-Like Receptors in Intestinal Homeostasis and Epithelial Tissue Repair

International Journal of Molecular Sciences

Marianna Parlato¹ 

[1] Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; E-Mail:

关键词: nucleotide-binding and oligomerization domain-like receptors (NLRs);    intestinal epithelial cells (IECs);    wound healing;    colitis;    inflammatory bowel diseases (IBD);    inflammasome;    growth factors;    innate immunity;    toll-like receptors (TLRs);   

DOI  :  10.3390/ijms15069594

来源: mdpi

【 摘 要 】

The intestinal epithelium constitutes a dynamic physical barrier segregating the luminal content from the underlying mucosal tissue. Following injury, the epithelial integrity is restored by rapid migration of intestinal epithelial cells (IECs) across the denuded area in a process known as wound healing. Hence, through a sequence of events involving restitution, proliferation and differentiation of IECs the gap is resealed and homeostasis reestablished. Relapsing damage followed by healing of the inflamed mucosa is a hallmark of several intestinal disorders including inflammatory bowel diseases (IBD). While several regulatory peptides, growth factors and cytokines stimulate restitution of the epithelial layer after injury, recent evidence in the field underscores the contribution of innate immunity in controlling this process. In particular, nucleotide-binding and oligomerization domain-like receptors (NLRs) play critical roles in sensing the commensal microbiota, maintaining homeostasis, and regulating intestinal inflammation. Here, we review the process of intestinal epithelial tissue repair and we specifically focus on the impact of NLR-mediated signaling mechanisms involved in governing epithelial wound healing during disease.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.